Dr Martin R Lindley
Founder of the TCB
web links : ORCID - Research Gate - Google Scholar - Loughborough University staff page
email m.r.lindley@lboro.ac.uk
Senior Lecturer in Exercise Physiology and Biochemistry
Moving from Indiana University USA to Loughborough University in 2003 I wanted to further investigate the biological mechanisms underpinning the proposed action of dietary fatty acids. To this end I embarked upon collaborative research projects with a number of key academics from Human Biology, Sport Science and Chemistry departments here at Loughborough University. Initially PhD student projects within Human Biology (Dr Mastana PhD student Ash Kumar) looking at dietary fish oil and respiratory physiology (EIB), Synthetic Chemistry (Dr M Kimer + Dr G Pritchard PhD student Natalie Brown) looking at possible novel synthetic pathways towards n-3 fatty acid derivatives and Analytical Chemistry (Prof P Thomas PhD student Liam Heaney) looking at exhaled breath profiles in exercise. These projects set the foundations for the creation of the TCB research group and the successful application for a funded mini-Centre for Doctoral training (AIM).
My aims moving forward are to develop the TCB research group and continue to look into the basic and fundamental mechanisms of action of a range of fatty acids to then allow the translation of this basic science into applied applications for Sports Performance, Exercise Capacity, General Health and Specific Disease Treatments.
Current Research
Epigenetic and mechanistic effects of Bioactive Lipid derived mediators Dr Mastana + Dr Reynolds (Chemistry) - PhD student Beth Hussey
The effects of Fish oil on sports performance - Dr Mastana Loughborough University - PhD student Lynsey Wilson.
The feasibility and effectiveness of lower limb eccentric training in patients with Chronic Obstructive Pulmonary Disease – developing exercise testing methodologies in healthy subjects - Prof M. Steiner and Dr R. Evans, Department of Respiratory Medicine Glenfield Hospital Leicester UK -PhD student Tom Ward
Profiling volatile compounds in exhaled breathe in health and exercise - Prof P Thomas Loughborough University -Dr Liam Heaney
Impact of dietary fish oil supplementation on exercise performance and muscle blood flow/oxygenation - PhD student - Lucy Hale University of Kent
Recent Publications (2019)
Hunter, D.J. James, L., Hussesy, B., Wadley, A.J., Lindley, M.R. and Mastanan,S.S. (2019) Impact of aerobic exercise on fatty acid supplementation on global and gene-specific DNA methylation. Epigenetics. Feb 14 Doi:10.1080/15592294.2019.1582276
Capel. N. J., Lindley, M. R., Pritchard, G. J., Kimber, M. C. (2019) Indium-mediated 2-Oxonia Cope rearrangement of 1,4-dienols to 1,3-dienols. ACS Omega 4 785.
Cameron, N and Lindley, M.R. (IN press) Body size and anthropometric measurements. In Cotes, J. (Ed) Lung Function : Physiology, Measurement and Application in Medicine 7th ed. Wiley-Blackwell,
Youdell, D and Lindley, M.R. (In press). Social Theory, Biological Sciences and the Sociology of Knowledge in Education In: Andrew Brown & Emma Wisby (Eds) Knowledge, Policy and Practice: the struggle for social justice in education, London UCL IOE Press
2018
Takeda, K., Kitaoka, Y., Watanabe, K., Miyakawa, S., Lindley, M.R. and Takemasa, T. (2018). Effects of eicosapentaenoic acid intake on denervation-induced mitochondrial adaption in mouse skeletal muscle. The Journal of Physical fitness and sports medicine. 7(5) 261-267
Youdell, D and Lindley, M.R. (2018) Biosocial Education : The social and biological entanglements of learning. Routledge ISBN: 9781315226408
Baker, L.A., Martin, N.R.W., Kimber, M.C., Pritchard, G.J., Lindley, M.R. and Lewis, M.P. (2018). Resolvin E1 (Rv E1) attenuates LPS indiced inflammation and subsequent atrophy in C2C12 myotubes. J Cell Biochem. Jul;119(7):6094-6013
Kayleigh L. Arthur, K.L., Wilson, L.S., Turner, M.A., Lindley M.R., Reynolds, J.C. and Creaser, C.S. (2018). The determination of salivary oxypurines before and after exercise by combined liquid chromatography-field asymmetric waveform ion mobility spectrometry-time-of-flight mass spectrometry. Int J of Ion Mob Spec.
2017
P. Perez, E. Palmer, C. Aldcroft, H. Moore, A. Baker. M.H. Allen, J. Jones, C. S. Creaser, M.R. Lindley, M.A. Turner, J.C Reynolds (2017) Direct Analysis of Volatile Organic Compounds in Foods by Headspace Extraction Atmospheric Pressure Chemical Ionisation Mass Spectrometry. Rapid communications in mass spectrometry. Nov 30;31(22):1947-1956
Heaney, L.M. & Lindley, M.R. (2017) Translation of exhaled breath volatile analyses to sport and exercise applications. Metabolomics November 13: 139.
Hussey, B., Lindley, M.R. and Mastana, S.S. (2017) Epigenetics and Epigenomics: the future of nutritional interventions? Future Science. Awaiting DOI
Khan, N and Lindley, M.R. (2017) Future directions on sex differences in athletes with asthma and exercise-induced bronchoconstriction. Future Science awaiting DOI
Mastana, S.S., Prakash, S., Akam, E.C., Kirby, M., Lindley, M.R., Sinha, N. and Agrawal, S. (2017). Genetic association of pro-inflammatory cytokine gene polymorphisms with coronary artery disease (CAD) in a North Indian population. Gene. awaiting DOI
Hussey, B., Lindley, M.R. and Mastana, S.S. (2017) Omega 3 fatty acids, inflammation and DNA methylation: an overview. Clinical Lipidology Published online 2nd May 2017 12(1)24-32
Lee, R.J., Lindley, M.R., Pritchard, G.J. and Kimber, M.C. (2017) A biosynthetically inspired route to substituted furans using the Appel reaction: total synthesis of the furan fatty acid F5. Chemical communications. June 47; (53) 6327-6330
Featured Publications:
Kumar, A., Lindley, M.R. and Mastana, S.S. (2014) A time efficient adaptation of GC-FID method for the analysis of PBMC lipid composition. Journal of Biochemical Techniques. 5(3) 760-764.
Shei, R.J., Lindley, M.R. and Mickleborough, T.D.(2014). Omega-3 Polyunsaturated Fatty Acids in the Optimization of Physical Performance. MilitaryMedicine. 2014 Nov;179(11S):144-156.
Mickleborough T,D. and Lindley, M.R. (2014). The Effect of Combining Fish Oil and Vitamin C on Airway Inflammation and Hyperpnea-Induced Bronchoconstriction in Asthma. Journal of Allergy and Therapy 5:184.
Mastana, S.S Kumar, A. and Lindley, M.R. (2013) Influence of glutathione S-transferase polymorphisms (GSTT1, GSTM1, GSTP1) on type 2 diabetes mellitus (T2D) risk in an endogenous population from North India. Molecular Biology Reports. 40:7103–7110
Gleeson, M., Bishop, N.C., Stensel, D.J., Lindley, M.R., Mastana, S.S. and Nimmo, M.A.(2011) The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nature Reviews : Immunology (Aug 5;11(9):607-15.
Calder, P.C., Lindley M.R., Burke, L.M., Stear, S.J and Castell, L.M. (2010). A-Z of nutritional supplements : dietary supplements, sports nutrition foods and ergogenic aids for health and performance: part 14. British Journal of Sports Medicine .44 : 1065-1067.
Mickleborough T.D., Tecklenburg, S.L., Montgomery, G.S. and Lindley, M.R. (2009). Eicosapentaenoic acid is more effective than docosahexaenoic acid in inhibiting pro-inflammatory mediator production and transcription from LPS-induced human asthmatic alveolar macrophage cells. Clinical Nutrition. Feb 28 (1) 71-77.
Ionescu, A.A., Mickleborough, T.D., Bolton, C.E., Lindley, M.R., Nixon, L.S., Dunseath, G., Luzio, S., Owens D.R. and Shale, D.J. (2006).The systematic inflammatory response to exercise in adults with cystic fibrosis. Journal of Cystic Fibrosis. 5 (2), 105-112
Mickleborough, T.D.., Ionescu, A.A., Lindley, M.R. and Fly, A.D. (2006) Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma. Chest. 29 (1), 39-49.
Mickleborough, T.D., Murray, R. Ionescu, A.A. and Lindley, M.R. (2003). Fish oil Supplementation reduces the severity of exercise-induced bronchoconstriction in elite athletes. American Journal of Respiratory and Critical Care Medicine. Vol 168, Issue 10. pp 1181-1189
Book Chapters
Calder, P.C. and Lindley M.R. (2015) Fish Oils. In Castell, L. (Ed) Book of Nutritional Supplements, A-Z Guide. LondonRoutledge
Lindley M.R and Youdell, D. (2015) Bio-social mappings of the effects and affects of physical activity of/on young bodies. In Symeon Dagkas & Lisette Burrows (Eds) Families, Young People, Physical Activity and Health: Critical Perspectives. London, Routledge.
Mickleborough, T.D. and Lindley, M.R. Dietary Omega-3 Fatty Acids and Asthma: Is There a Connection? In : Food Science Research and Technology (2009) Nova Science Publishers. Hauppauge, NY. ISBN: 978-1-60741-848-1
Mickleborough, T.D. and Lindley, M.R. Fish Oil Supplementation and Asthma. In : Fish Oils and Health Research. (2008) Nova Science Publishers. Hauppauge, NY. ISBN-10: 1604564288 ISBN-13: 978-1604564280
External Activities
Editorial Board Member
Scientific Reports: Nature publishing group
Journal Referee
Medicine and Science in Sport and Exercise
Journal of Sports Science
Annals of Human Biology
Journal of Science and Medicine in Sport
Ergonomics
The Journal of Swimming research
Learned Societies and Professional Affiliations
Royal Society of Biology (member)
Biochemical Society (member)
British Association of Sports and Exercise Science BASES(member)
American College of Sports Medicine ACSM (member)
Collaboration for Leadership in Applied Health Research and Care CLAHRC – East Midlands (Faculty)
Higher Education Academy (Fellow)
British Association of Sports Medicine BASM
British Thoracic Society
European Respiratory Society
American Thoracic Society
International Society for the study of fatty acids and lipids
Visiting Titles
Adjunct Assistant Professor - Indiana University
Conference Presentations / Invited Lectures
2016 Conference Symposium – European College of Sport Science (7th-11th July Vienna, Austria) Title: Nutritional supplements to improve health and performance. Chair: Jo Bowtell Presentations: 1. Antioxidants - Michaelis Nikolaidis - Greece 2. Omega-3 fatty acids - Martin Lindley - UK, Loughborough 3. Polyphenols - Jo Bowtell - UK, Exeter
2015 Conference Symposium – 9th International Congress of Comparative Physiology and Biochemistry : (23-28th August Cracow Poland) Physiology and Biochemistry of w-3 PUFA’s and their bioactive derivatives
2014 Invited participant Research Seminar – European Respiratory Society : Human Translational Medicine: A key bridge for the development of new drugs for severe asthma, COPD and ILD. (12-14th November ) Dublin Ireland
2014 Invited presentation : English Institute of Sport Nutritional and Biochemical aspects of Omega-3 polyunsaturated fatty acids (14th January 2014) Loughborough UK
2012 Conference Symposium – American College of Sports Medicine : Omega-3 Fatty Acids, Exercise and Respiratory Health (3rd June 2012) Indianapolis USA
2012 Conference Symposium - International Convention on Science, Education & Medicine in Sport New Horizons in the Evaluation of the Young Athlete : Exercise and the Respiratory System. (Glasgow UK
2011 Invited presentation – English Institute of Sport : Fish Oil, Diet Nutrition and Performance Sport City Manchester UK
2008 Invited presentation– UK Sport and English Institute of Sport : Immunity Master Class : Panel presentation for Olympic coach and managers (14th May 2008) London UK
2008 Invited Keynote - Association for Respiratory Technology and Physiology Annual meeting. Physiological preparation for Multi-sport competitions. (Hinkley, UK)
2004 Invited presentation : University of Nottingham School of Community Health Sciences Division of Epidemiology and Public Health, Nottingham City Hospital, Contact Prof J. Britton entitled “Dietary Supplementation and Exercise-Induced Asthma: Myth or reality? ” June 2004.
2002 Invited presentation :University of Wales College of Medicine Section of Respiratory and Communicable Diseases, contact Prof D. Shale. Entitled “Respiratory Muscles – Function and Fatigue”. 20th November, 2002