Moving from Indiana University USA to Loughborough University in 2003 I wanted to further investigate the biological mechanisms underpinning the proposed action of dietary fatty acids. To this end I embarked upon collaborative research projects with a number of key academics from Human Biology, Sport Science and Chemistry departments here at Loughborough University. Initially PhD student projects within Human Biology (Dr Mastana PhD student Ash Kumar) looking at dietary fish oil and respiratory physiology (EIB), Synthetic Chemistry (Dr M Kimer + Dr G Pritchard PhD student Natalie Brown) looking at possible novel synthetic pathways towards n-3 fatty acid derivatives and Analytical Chemistry (Prof P Thomas PhD student Liam Heaney) looking at exhaled breath profiles in exercise. These projects set the foundations for the creation of the TCB research group and the successful application for a funded mini-Centre for Doctoral training (AIM).

My aims moving forward are to develop the TCB research group and continue to look into the basic and fundamental mechanisms of action of a range of fatty acids to then allow the translation of this basic science into applied applications for Sports Performance, Exercise Capacity, General Health and Specific Disease Treatments.

Current Research

Epigenetic and mechanistic effects of Bioactive Lipid derived mediators Dr Mastana + Dr Reynolds (Chemistry) - PhD student Beth Hussey

The effects of Fish oil on sports performance - Dr Mastana Loughborough University - PhD student Lynsey Wilson.

The feasibility and effectiveness of lower limb eccentric training in patients with Chronic Obstructive Pulmonary Disease – developing exercise testing methodologies in healthy subjects - Prof M. Steiner and Dr R. Evans, Department of Respiratory Medicine Glenfield Hospital Leicester UK -PhD student Tom Ward

Profiling volatile compounds in exhaled breathe in health and exercise - Prof P Thomas  Loughborough University -Dr Liam Heaney

Impact of dietary fish oil supplementation on exercise performance and muscle blood flow/oxygenation - PhD student - Lucy Hale University of Kent

Recent Publications (2019)

  • Hunter, D.J. James, L., Hussesy, B., Wadley, A.J., Lindley, M.R. and Mastanan,S.S. (2019) Impact of aerobic exercise on fatty acid supplementation on global and gene-specific DNA methylation.  Epigenetics. Feb 14 Doi:10.1080/15592294.2019.1582276

  • Capel. N. J., Lindley, M. R., Pritchard, G. J., Kimber, M. C. (2019) Indium-mediated 2-Oxonia Cope rearrangement of 1,4-dienols to 1,3-dienols. ACS Omega 4 785.

  • Cameron, N and Lindley, M.R. (IN press) Body size and anthropometric measurements. In Cotes, J. (Ed) Lung Function : Physiology, Measurement and Application in Medicine 7th ed. Wiley-Blackwell,

  •  Youdell, D and Lindley, M.R. (In press). Social Theory, Biological Sciences and the Sociology of Knowledge in Education In: Andrew Brown & Emma Wisby (Eds) Knowledge, Policy and Practice: the struggle for social justice in education, London UCL IOE Press

    2018

  • Takeda, K., Kitaoka, Y., Watanabe, K., Miyakawa, S., Lindley, M.R. and Takemasa, T. (2018). Effects of eicosapentaenoic acid intake on denervation-induced mitochondrial adaption in mouse skeletal muscle. The Journal of Physical fitness and sports medicine. 7(5) 261-267

  • Youdell, D and Lindley, M.R. (2018) Biosocial Education : The social and biological entanglements of learning. Routledge ISBN: 9781315226408

  • Baker, L.A., Martin, N.R.W., Kimber, M.C., Pritchard, G.J., Lindley, M.R. and Lewis, M.P. (2018). Resolvin E1 (Rv E1) attenuates LPS indiced inflammation and subsequent atrophy in C2C12 myotubes. J Cell Biochem.  Jul;119(7):6094-6013

  • Kayleigh L. Arthur, K.L., Wilson, L.S., Turner, M.A., Lindley M.R., Reynolds, J.C. and Creaser, C.S. (2018). The determination of salivary oxypurines before and after exercise by combined liquid chromatography-field asymmetric waveform ion mobility spectrometry-time-of-flight mass spectrometry. Int J of Ion Mob Spec.

    2017

  • P. Perez, E. Palmer, C. Aldcroft, H. Moore, A. Baker. M.H. Allen, J. Jones, C. S. Creaser, M.R. Lindley, M.A. Turner, J.C Reynolds (2017) Direct Analysis of Volatile Organic Compounds in Foods by Headspace Extraction Atmospheric Pressure Chemical Ionisation Mass Spectrometry. Rapid communications in mass spectrometry. Nov 30;31(22):1947-1956

  • Heaney, L.M. & Lindley, M.R. (2017) Translation of exhaled breath volatile analyses to sport and exercise applications. Metabolomics November 13: 139.

  • Hussey, B., Lindley, M.R. and Mastana, S.S. (2017) Epigenetics and Epigenomics: the future of nutritional interventions? Future Science. Awaiting DOI

  • Khan, N and Lindley, M.R. (2017) Future directions on sex differences in athletes with asthma and exercise-induced bronchoconstriction. Future Science awaiting DOI

  • Mastana, S.S., Prakash, S., Akam, E.C., Kirby, M., Lindley, M.R., Sinha, N. and Agrawal, S. (2017). Genetic association of pro-inflammatory cytokine gene polymorphisms with coronary artery disease (CAD) in a North Indian population. Gene. awaiting DOI

  • Hussey, B., Lindley, M.R. and Mastana, S.S. (2017) Omega 3 fatty acids, inflammation and DNA methylation: an overview. Clinical Lipidology Published online 2nd May 2017 12(1)24-32

  • Lee, R.J., Lindley, M.R., Pritchard, G.J. and Kimber, M.C. (2017) A biosynthetically inspired route to substituted furans using the Appel reaction: total synthesis of the furan fatty acid F5. Chemical communications. June 47; (53) 6327-6330

Featured Publications:

  1. Kumar, A., Lindley, M.R. and Mastana, S.S. (2014) A time efficient adaptation of GC-FID method for the analysis of PBMC lipid composition. Journal of Biochemical Techniques. 5(3) 760-764.

  2. Shei, R.J., Lindley, M.R. and Mickleborough, T.D.(2014). Omega-3 Polyunsaturated Fatty Acids in the Optimization of Physical Performance. MilitaryMedicine. 2014 Nov;179(11S):144-156.

  3. Mickleborough T,D. and Lindley, M.R. (2014). The Effect of Combining Fish Oil and Vitamin C on Airway Inflammation and Hyperpnea-Induced Bronchoconstriction in Asthma. Journal of Allergy and Therapy 5:184.

  4. Mastana, S.S Kumar, A. and Lindley, M.R. (2013) Influence of glutathione S-transferase polymorphisms (GSTT1, GSTM1, GSTP1) on type 2 diabetes mellitus (T2D) risk in an endogenous population from North India. Molecular Biology Reports. 40:7103–7110

  5. Gleeson, M., Bishop, N.C., Stensel, D.J., Lindley, M.R., Mastana, S.S. and Nimmo, M.A.(2011) The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nature Reviews : Immunology (Aug 5;11(9):607-15.

  6. Calder, P.C., Lindley M.R., Burke, L.M., Stear, S.J and Castell, L.M. (2010). A-Z of nutritional supplements : dietary supplements, sports nutrition foods and ergogenic aids for health and performance: part 14. British Journal of Sports Medicine .44 : 1065-1067.

  7. Mickleborough T.D., Tecklenburg, S.L., Montgomery, G.S. and Lindley, M.R. (2009). Eicosapentaenoic acid is more effective than docosahexaenoic acid in inhibiting pro-inflammatory mediator production and transcription from LPS-induced human asthmatic alveolar macrophage cells. Clinical Nutrition. Feb 28 (1) 71-77.

  8. Ionescu, A.A., Mickleborough, T.D., Bolton, C.E., Lindley, M.R., Nixon, L.S., Dunseath, G., Luzio, S., Owens D.R. and Shale, D.J. (2006).The systematic inflammatory response to exercise in adults with cystic fibrosis. Journal of Cystic Fibrosis. 5 (2), 105-112

  9. Mickleborough, T.D.., Ionescu, A.A., Lindley, M.R. and Fly, A.D. (2006) Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma. Chest. 29 (1), 39-49.

  10. Mickleborough, T.D., Murray, R. Ionescu, A.A. and Lindley, M.R. (2003). Fish oil Supplementation reduces the severity of exercise-induced bronchoconstriction in elite athletes. American Journal of Respiratory and Critical Care Medicine. Vol 168, Issue 10. pp 1181-1189

Book Chapters

  1. Calder, P.C. and Lindley M.R. (2015) Fish Oils. In Castell, L. (Ed) Book of Nutritional Supplements, A-Z Guide. LondonRoutledge

  2. Lindley M.R and Youdell, D. (2015) Bio-social mappings of the effects and affects of physical activity of/on young bodies. In Symeon Dagkas & Lisette Burrows (Eds) Families, Young People, Physical Activity and Health: Critical Perspectives. London, Routledge.

  3. Mickleborough, T.D. and Lindley, M.R. Dietary Omega-3 Fatty Acids and Asthma: Is There a Connection? In : Food Science Research and Technology (2009) Nova Science Publishers. Hauppauge, NY. ISBN: 978-1-60741-848-1

  4. Mickleborough, T.D. and Lindley, M.R. Fish Oil Supplementation and Asthma. In : Fish Oils and Health Research. (2008) Nova Science Publishers. Hauppauge, NY. ISBN-10: 1604564288 ISBN-13: 978-1604564280

External Activities

Editorial Board Member

Scientific Reports: Nature publishing group

Journal Referee

  • Medicine and Science in Sport and Exercise

  • Journal of Sports Science

  • Annals of Human Biology

  • Journal of Science and Medicine in Sport

  • Ergonomics

  • The Journal of Swimming research

Learned Societies and Professional Affiliations

  • Royal Society of Biology (member)

  • Biochemical Society (member)

  • British Association of Sports and Exercise Science BASES(member)

  • American College of Sports Medicine ACSM (member)

  • Collaboration for Leadership in Applied Health Research and Care CLAHRC – East Midlands (Faculty)

  • Higher Education Academy (Fellow)

  • British Association of Sports Medicine BASM

  • British Thoracic Society

  • European Respiratory Society

  • American Thoracic Society

  • International Society for the study of fatty acids and lipids

Visiting Titles

  • Adjunct Assistant Professor - Indiana University

Conference Presentations / Invited Lectures

  • 2016 Conference Symposium – European College of Sport Science (7th-11th July Vienna, Austria) Title: Nutritional supplements to improve health and performance. Chair: Jo Bowtell Presentations: 1. Antioxidants - Michaelis Nikolaidis - Greece 2. Omega-3 fatty acids - Martin Lindley - UK, Loughborough 3. Polyphenols - Jo Bowtell - UK, Exeter

  • 2015 Conference Symposium – 9th International Congress of Comparative Physiology and Biochemistry : (23-28th August Cracow Poland) Physiology and Biochemistry of w-3 PUFA’s and their bioactive derivatives

  • 2014 Invited participant Research Seminar – European Respiratory Society : Human Translational Medicine: A key bridge for the development of new drugs for severe asthma, COPD and ILD. (12-14th November ) Dublin Ireland

  • 2014 Invited presentation : English Institute of Sport Nutritional and Biochemical aspects of Omega-3 polyunsaturated fatty acids (14th January 2014) Loughborough UK

  • 2012 Conference Symposium – American College of Sports Medicine : Omega-3 Fatty Acids, Exercise and Respiratory Health (3rd June 2012) Indianapolis USA

  • 2012 Conference Symposium - International Convention on Science, Education & Medicine in Sport New Horizons in the Evaluation of the Young Athlete : Exercise and the Respiratory System. (Glasgow UK

  • 2011 Invited presentation – English Institute of Sport : Fish Oil, Diet Nutrition and Performance Sport City Manchester UK

  • 2008 Invited presentation– UK Sport and English Institute of Sport : Immunity Master Class : Panel presentation for Olympic coach and managers (14th May 2008) London UK

  • 2008 Invited Keynote - Association for Respiratory Technology and Physiology Annual meeting. Physiological preparation for Multi-sport competitions. (Hinkley, UK)

  • 2004 Invited presentation : University of Nottingham School of Community Health Sciences Division of Epidemiology and Public Health, Nottingham City Hospital, Contact Prof J. Britton entitled “Dietary Supplementation and Exercise-Induced Asthma: Myth or reality? ” June 2004.

  • 2002 Invited presentation :University of Wales College of Medicine Section of Respiratory and Communicable Diseases, contact Prof D. Shale. Entitled “Respiratory Muscles – Function and Fatigue”. 20th November, 2002